The high-end property has 41 rooms across a former hunting lodge and Grade II-listed 18th century brew house.
It is the result of a six-year, multimillion-pound renovation that sees it open as a hotel for the first time.
The main house is home to the three-bedroom Duke of Marlborough Suite while historic features are preserved throughout the hotel.
Drinking and dining options include the Churchill Bar, Cedar restaurant and the Drawing Room for afternoon teas.
Meeting and event facilities comprise the Winter Garden and six further rooms ranging in capacity from six to 120 guests, plus a private screening room.
There is also an extensive spa, indoor pool and gym, while activities on offer include clay pigeon shooting, horse-riding and cooking classes.
“Set amidst a former royal hunting ground, The Langley seamlessly blends historic country manor grandeur with modern convenience,” says Jenni Benzaquen, Vice President of Luxury Brands – Europe for Marriott International.
“The Langley joins a strong portfolio of three other Luxury Collection hotels in England, all of which are located in London, and together they offer our guests the opportunity to explore the best of both the city and the countryside.”